BONEMET Effects of a treatment with Denosumab, applied together with either Nivolumab oder Pembrolizumab, in patients with skin cancer and bone metastases (Aktiv)
HUYA Eine multizentrische, randomisierte, doppelblinde Phase-3-Studie zu HBI-8000 in Kombination mit Nivolumab im Vergleich zu Placebo mit Nivolumab bei Patienten mit nicht resezierbarem oder metastasiertem Melanom, die zuvor nicht mit PD-1- oder PD-L1-Inhibitoren behandelt wurden (Aktiv)
SNEPS Comparing SLNE With or Without Preoperative Hybrid SPECT/CT in Melanoma (Aktiv)
Erstlinie
20210031 A Randomized, Double-Blind Study Evaluating the Efficacy, Safety, and Immunogenicity of ABP 206 Compared with OPDIVO (Nivolumab) in Subjects with Treatment-Naive Unresectable or Metastatic Melanoma (Aktiv)
CA224-127 A Phase 3, Randomized, Open-label, Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination Versus Intravenous Nivolumab + Relatlimab Fixed-dose Combination in Participants With Previously Untreated Metastatic or Unresectable Melanoma (Aktiv)
IMC-F106C-301 A Phase 3 Randomized, Controlled Study of IMC-F106C Plus Nivolumab Versus Nivolumab Regimens in HLA-A*02:01-Positive Participants With Previously Untreated Advanced Melanoma (PRISM-MEL-301) (Aktiv)
IO102-IO103-013 An open-label, randomized, Phase 3 clinical trial of IO102-IO103 in combination with pembrolizumab versus pembrolizumab alone in patients with previously untreated, unresectable, or metastatic (advanced) melanoma (Aktiv)
MK-3475-E40 Phase II, Multi-cohort Trial of Neoadjuvant and Post-surgery IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Selected Resectable Tumors (Aktiv)
R3767-ONC-2011 A Phase 3 Trial of Fianlimab (REGN3767, Anti-LAG-3) + Cemiplimab Versus Pembrolizumab in Patients With Previously Untreated Unresectable Locally Advanced or Metastatic Melanoma (Aktiv)
STARBOARD EINE PHASE 3, RANDOMISIERTE, DOPPELBLINDE STUDIE VON ENCORAFENIB UND BINIMETINIB PLUS PEMBROLIZUMAB GEGEN PLACEBO PLUS PEMBROLIZUMAB BEI TEILNEHMER MIT BRAF V600E/K MUTATION-POSITIVE METASTATISCHE ODER NICHT RESEZIERTES LOKAL FORTGESCHRITTENES MELANOM (Aktiv)
Zweitlinie oder später
20220083 A Randomized, Double-blind Study Evaluating Pharmacokinetic Similarity of ABP 206 Compared With OPDIVO (Nivolumab) in Resected Stage III or Stage IV Melanoma Subjects in the Adjuvant Setting (Aktiv)
C-800-23 A Multicohort, Open Label, Phase 2 Study of Botensilimab (AGEN1181) for Treatment of Advanced Melanoma Refractory to Prior Checkpoint Inhibitor Therapy (C-800-23) (Aktiv)
C4221023/KEYNOTE PNC92 A PHASE 2, RANDOMIZED, OPEN-LABEL STUDY OF ENCORAFENIB AND BINIMETINIB PLUS PEMBROLIZUMAB VERSUS NIVOLUMAB AND IPILIMUMAB IN PARTICIPANTS WITH BRAF V600E/K MUTATION-POSITIVE MELANOMA WHO PROGRESSED DURING OR AFTER PRIOR TREATMENT WITH ANTI-PD-1 THERAPY (Aktiv)
CDYP688A12101 A Phase I/II, Multi-center, Open Label Study of DYP688 in Patients With Metastatic Uveal Melanoma (MUM) and Other GNAQ/11 Mutant Melanomas (Aktiv)
GO42273 This study will evaluate the safety, pharmacokinetics, and activity of belvarafenib as a single agent and in combination with either cobimetinib or cobimetinib plus nivolumab in patients with NRAS-mutant advanced melanoma who have received anti-PD-1/PD-L1 therapy. (Aktiv)
IMCgp100-203 Phase 2/3 Randomized Study of Tebentafusp as Monotherapy and in Combination With Pembrolizumab Versus Investigator's Choice in HLA-A*02:01-positive Participants With Previously Treated Advanced Melanoma (TEBE-AM) (Aktiv)
MB-CART20.1 Multizentrische Phase-I-Studie mit MB-CART20.1 zur Behandlung von Patienten mit metastasierendes Melanom (Aktiv)
MK-3475 Study of Pembrolizumab (MK-3475) in Children (Aktiv)
MONETTE A Randomised, Open-Label, Phase 2 Study of Ceralasertib Monotherapy and Ceralasertib plus Durvalumab in Patients with Unresectable or Advanced Melanoma and Primary or Secondary Resistance to PD-(L)1 Inhibition Advanced Melanoma (Aktiv)
Novartis CFKA115A12101 A Phase I, Open-label, Multi-center Study of KFA115 as a Single Agent and in Combination With Tislelizumab in Patients With Select Advanced Cancers (Aktiv)
OMNIA-1 (ANV419-10) A Phase 1/2 Study of ANV419 as Monotherapy or in Combination With Anti PD1 or Anti-CTLA-4 Antibody Following Anti PD1/Anti-PDL1 Antibody Treatment in Patients With Unresectable or Metastatic Cutaneous Melanoma (Aktiv)
PROMIT Preconditioning of Tumor, Tumor Microenvironment and the Immune System to Immunotherapy (Aktiv)
Relativity A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy with Relatlimab and Nivolumab Fixed-dose Combination versus Nivolumab Monotherapy after Complete Resection of Stage III-IV Melanoma (Aktiv)
SORATRAM Multizentrische Basket-Studie zur kombinierten CRAF- und MEK-Inhibition bei fortgeschrittenen Tumorerkrankungen mit BRAF-Mutationen und eingeschränkter Kinase-Aktivität (Aktiv)
VALO-001 Phase I Studie zu einer Erstlinientherapie bei Nicht-Kleinzelligem Lungenkarzinom, Schwarzem Hautkrebs oder Brustkrebs (Aktiv)