AARON Eine offene Phase-II-Studie von Relatlimab (BMS-986016) mit Nivolumab (BMS-936558) in Kombination mit 5-Azacytidin zur Behandlung von Patienten mit refraktärer/rezidivierter akuter myeloischer Leukämie und neu diagnostizierten älteren Patienten mit akuter myeloischer Leukämie (Aktiv)
Avencell AVC-201-01 Multicenter, Open-label, Phase 1 Study of Allo-RevCAR01-T-CD123 Consisting of Genetically Modified T cells Carrying Reverse Chimeric Antigen Receptors (Allo-RevCAR01-T) in Combination With CD123 Target Module (R-TM123) for the Treatment of Patients With Selected Hematologic Malignancies Positive for CD123. (Aktiv)
CHDM201H12101C HDM201 in Combination With MBG453 or Venetoclax in Patients With Acute Myeloid Leukemia (AML) or High-risk Myelodysplastic Syndrome (MDS) (Aktiv)
HaploMUDStudy Phase II Studie zu Spendertypen für die allogene Stammzelltransplantation bei akuter Leukämie (Aktiv)
Janssen 75276617ALE1002 A Phase 1b Study of JNJ-75276617 in Combination With AML Directed Therapies for Participants With Acute Myeloid Leukemia Harboring KMT2A or NPM1 Alterations (Aktiv)
NIFAR Phase 1/2 trial to test Nivolumab in treatment failure of Acute Myeloid Leukemia (AML) after stem cell transplantation by a allogenic donor (allo-SCT) (Aktiv)
PALOMA Comparison of Therapies Before Stem Cell Transplantation in Patients With Higher Risk MDS and Oligoblastic AML (PALOMA) (Aktiv)
PEMAZA MRD-guided Treatment in NPM1mut AML Patients (PEMAZA) (Aktiv)
SAL-AML Register AML-Register und Biomaterialdatenbank der Studienallianz Leukämie (SAL) (Aktiv)
TUD-APOLLO-064 Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia (TUD-APOLLO-064) (Aktiv)
Erstlinie
AMLSG 24-15 Study of Vosaroxin With Azacitidine in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome With Excess Blasts-2 (Aktiv)
AMLSG 29-18 / HOVON 150 A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy (Aktiv)
AMLSG 30-18 Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics (Aktiv)
CPKC412A2218-Midostaurin_FLT3-AML A Phase II, Open-label, Single Arm Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Twice Daily Midostaurin (PKC412) Combined With Standard Chemotherapy and as a Single Agent Post-consolidation Therapy in Children With Untreated FLT3-mutated AML (Aktiv)
DECIDER-2_AMLSG 32-21 Prospective randomized multicenter phase III trial of decitabine and venetoclax administered in combination with all-trans retinoic acid or placebo in patients with acute myeloid leukemia who are ineligible for induction chemotherapy (Aktiv)
DaunoDouble Randomisierter Vergleicher zwischen zwei Dosierungen von Daunorubicin und zwischen Einfach- und Doppel-Induktionstherapie bei erwachsenen Patienten mit Akuter Myeloischer Leukämie ≤ 60 Jahre (Aktiv)
MOSAIC Addition of midostaurin and gemtuzumab ozogamicin to standard chemotherapy with cytarabine and daunorubicin in patients with newly diagnosed acute myeloid leukemia (Aktiv)
NAPOLEON National Acute Promyelocytic Leukemia (APL) Observational Study NAPOLEON-Registry of the German AML Intergroup (Aktiv)
STIMULUS-AML1 (CMBG453C12201) A Phase II Multi-center, Single Arm, Safety and Efficacy Study of MBG453 in Combination With Azacitidine and Venetoclax for the Treatment of Acute Myeloid Leukemia (AML) in Adult Patients Unfit for Chemotherapy (Aktiv)
WINK (SMS-0341_WiNK) A Trial to Evaluate the Safety and Efficacy of oNKord® in Subjects With Acute Myeloid Leukemia (Aktiv)
Zweitlinie oder später
DOSE ESCALATION OF RO7283420 IN AML EINE OFFENE, MULTIZENTRISCHE PHASE-I-STUDIE ZUR BEURTEILUNG DER SICHERHEIT, VERTRÄGLICHKEIT, PHARMAKOKINETIK UND PHARMAKODYNAMIK VON RO7283420 ALS EINZELWIRKSTOFF BEI HÄMATOLOGISCH UND MOLEKULAR REZIDIVIERTER/REFRAKTÄRER AKUTER MYELOISCHER LEUKÄMIE (Aktiv)
H3 Biomedicine Phase 1 Trial to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Splicing Modulator H3B-8800 (Aktiv)
KO-MEN-001 Eine Phase I/IIa-First-in-Human-Studie am Menschen mit dem Menin-MLL(KMT2A)-Inhibitor KO-539 bei Patienten mit rezidivierter oder refraktärer akuter myeloischer Leukämie (Aktiv)
RELAX (AML) Trial for Relapsed or Refractory AML Patients Combining Cytarabine and Mitoxantrone With Venetoclax (RELAX) (Aktiv)
UC02-123-01 Dose-escalating Trial With UniCAR02-T Cells and CD123 Target Module (TM123) in Patients With Hematologic and Lymphatic Malignancies (Aktiv)